Knee Osteoarthritis Pain Relief: Is Paracetamol Still Recommended?
Paracetamol for Osteoarthritis: Is It Still the First Choice for Knee Pain? "Safe Does Not Always Mean Effective." Paracetamol (also known as acetaminophen) has long been one of the most commonly prescribed medications for osteoarthritis (OA). For decades, it was considered the first-line analgesic because of its favorable safety profile compared with non-steroidal anti-inflammatory drugs (NSAIDs). However, recent evidence and international guidelines have changed our understanding. While paracetamol may provide pain relief for some patients, its benefits in osteoarthritis are generally modest, and it should not be viewed as a standalone treatment. For patients with knee osteoarthritis, effective management requires a comprehensive rehabilitation approach that addresses pain, muscle weakness, biomechanics, weight, and functional limitations—not just medication. What is Paracetamol? Paracetamol is an analgesic (pain reliever) and antipyretic (fever-reducing) medicatio...